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The virus has also been referred to by the term "Indian Variant" as it was originally detected in India. It is identified as the 21A clade under the Nextstrain phylogenetic classification system. The Delta variant has mutations in the gene encoding the SARS-CoV-2 spike protein causing the substitutions D614G, T478K, P681R and L452R. By late July, it had also driven an increase in daily infections in parts of Asia, the United States, Australia, and New Zealand. It later contributed to a third wave in Fiji, the United Kingdom and South Africa, and the WHO warned in July 2021 that it could have a similar effect elsewhere in Europe and Africa. The variant is thought to be partly responsible for India's deadly second wave of the pandemic beginning in February 2021. On 15 June 2021, the Centers for Disease Control and Prevention (CDC) declared Delta a variant of concern. On, the WHO also classified this lineage VOC, and said that it showed evidence of higher transmissibility and reduced neutralisation. On, PHE changed their classification of lineage B.1.617.2 from a variant under investigation (VUI) to a variant of concern (VOC) based on an assessment of transmissibility being at least equivalent to B.1.1.7 ( Alpha variant) the UK's SAGE using May data estimated a "realistic" possibility of being 50% more transmissible. Immunity from previous recovery or COVID-19 vaccines are effective in preventing severe disease or hospitalisation from infection with the variant. In August 2021, Public Health England (PHE) reported secondary attack rate in household contacts of non-travel or unknown cases for Delta to be 10.8% vis-à-vis 10.2% for the Alpha variant the case fatality rate for those 386,835 people with Delta is 0.3%, where 46% of the cases and 6% of the deaths are unvaccinated and below 50 years old. It is thought to be one of the most transmissible respiratory viruses known. It has mutations in the gene encoding the SARS-CoV-2 spike protein causing the substitutions T478K, P681R and L452R, which are known to affect transmissibility of the virus as well as whether it can be neutralised by antibodies for previously circulating variants of the COVID-19 virus. The World Health Organization (WHO) indicated in June 2021 that the Delta variant is becoming the dominant strain globally. The Delta variant was named on and had spread to over 163 countries by 24 August 2021. It was first detected in India in late 2020. The Delta variant is a variant of SARS-CoV-2, the virus that causes COVID-19.